The current study looks at whether or not cell-free DNA levels in pregnant patients are related to:

• the clinical characteristics of preeclampsia
• the standard laboratory tests seen in patients with preeclampsia
• markers of inflammation,
• endothelial activation or injury (in other words injury to the inner
• layer of blood vessels often seen in preeclampsia)
• oxidative stress and
• cell-free fetal DNA levels.

How the study was performed? Blood samples of 67 women with preeclampsia were compared to 70 pregnant women without preeclampsia. The analysis looked at levels of cell- free DNA as well as standard laboratory parameters tests obtained in pregnant patients. The study concluded that levels of cell-free maternal and fetal DNA were higher in mothers with preeclampsia as shown below: The quantity of cell-free DNA did not correlate to other lab findings in preeclampsia (with the exception of liver enzyme changes) and did not correlate to the clinical characteristics in the mothers (such as body mass index). The authors conclude that the increased levels of cell free DNA may be triggered by low-level liver damage seen in patients with preeclampsia.

• What does this mean for patients?Currently, there is not enough support for analyzing cell-free DNA in most patients with preeclampsia. However, we appear to be on the cusp of a number of technological breakthroughs involving DNA based diagnostic tests which will allow us to make much earlier diagnoses. In current day medicine, HELLP syndrome is the most severe form of preeclampsia. (HELLP stands for Hemolysis, Elevated Liver enxymes, and Low Platelets). In order for this diagnosis to be made, the patient’s preeclampsia must get to the point where the liver cells are severely damaged and leaking enzymes.
• The results of the current study provide hope that we may be close to a point where an analysis of cell-free DNA can give information about early liver damage in patients with preeclampsia before they get to the point of having HELLP syndrome.
• A full copy of the study can be found here: http://www.biomedcentral.com/content/pdf/1471-2350-10-120.pdf
• For further reading regarding the use of cutting edge diagnostic techniques I would recommend the following blog: http://thedecisiontree.com/blog/

And the following books.

• The Decision Tree: Taking Control of Your Health in the New Era of Personalized Medicine
• The Future of Medicine: Megatrends in Health Care That Will Improve Your Quality of Life
• Genomic and Personalized Medicine, Two-Vol Set: V1-2

I am sharing a link to the audio from Twithear at the following link:

• Dr. Saul Weinreb on Preeclampsia part 1

• Dr. Saul Weinreb on Preeclampsia part 2

• Dr. Saul Weinreb on Preeclampsia part 3

• Dr. Saul Weinreb on Preeclampsia part 4

Dr. Weinreb’s site is highly informative, and I would recommend AskMyOBGYN.com to anyone with questions regarding pregnancy and gynecologic issues. Regular readers of my blog will also note that some of the articles at AskMyOBGYN.com are written by my friend Angela Davids, from www.KeepEmCookin.com.

I am also going to post a copy of this remix to my posterous blog and to preeclampsiaonline.net.

At present, the cause of preeclampsia is unknown.  However, it is clear that patients who have had preeclampsia are at risk for other cardiovascular conditions in later life.  Recently published studies now show that in addition to these concerns; patients who have had preeclampsia are also at risk for hypothyroidism later in life.

This presentation reviews why this is an important consideration for the long term health of these patients.